Expansion of CD3+CD56+ cytotoxic cells from patients with chronic lymphocytic leukemia: in vitro efficacy.
نویسندگان
چکیده
1999; 59:728-33. 5. Fiedler W, Graeven U, Ergun S, et al. Vascular endothelial growth factor, a possible paracrine growth factor in human acute myeloid leukemia. Blood 1997; 89:1870-5. 6. Perez-Atayde A, Sallan S, Tedrow U, Connors S, Allred E, Folkman J. Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia. Am J Pathol 1997; 150:815-21. 7. Hussong JW, Rodgers GM, Shami PJ. Evidence of increased angiogenesis in patients with acute myeloid leukemia. Blood 2000; 95:309-15. 8. Kini AR, Peterson LC, Kay NE. Evidence for abnormal angiogenesis in the bone marrow of patients with Bcell chronic lymphocytic leukemia. Blood 1998; 92 (Suppl 1):717a. 9. Molica S, Vitelli G, Levato D, Gandolfo GM, Liso V. Increased serum levels of vascular endothelial growth factor predict risk of progression in early B-cell chronic lymphocytic leukaemia. Br J Haematol 1999; 107: 605-10. 10. Chen HJ, Treweeke AT, Till KJ, et al. Vascular endothelial growth factor (VEGF) is produced by CLL cells and stimulates angiogenesis within lymphoreticular tissues. VIII International Workshop on CLL; Paris 29-31 October 1999; Abstract Book, pag. 43.
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عنوان ژورنال:
- Haematologica
دوره 85 10 شماره
صفحات -
تاریخ انتشار 2000